Clinical Trial: Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Clinical Significance of Supranormal Differential Renal Function in the Recovery of Unilateral Hydronephrosis After Surgery: Long-term Results

Brief Summary: The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (> 55%) in the DTPA renography will be analyzed.

Detailed Summary: To assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (> 55%) in the DTPA renography will be analyzed. Clinical parameters including age at the first visit, age at operation, gender, laterality, and follow-up period will be evaluated. To evaluate predictors of recovery from supranormal renal function according to the level of DRF, univariate and multivariate logistic regression analyses will be performed. Patients would be subcategorized into two groups; group A (DRF ≤60%) and group B (DRF >60%) in consideration of the mean value of preoperative DRF and each parameter of group A was compared to that of group B using independent sample's t test and chi square test. Kaplan-Meier analysis and log-rank test will be used to determine the difference of recovery time of obstructed hydronephrosis in each parameter.
Sponsor: Seoul National University Hospital

Current Primary Outcome: Hydronephrosis [ Time Frame: postop 6 months ]

The grade of hydronephrosis would be check at 6 months postoperatively.


Original Primary Outcome: Same as current

Current Secondary Outcome: renal parenchymal thickness [ Time Frame: postop 6 months ]

Renal parenchymal thickness was measured.


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: June 25, 2011
Date Started: June 2011
Date Completion:
Last Updated: April 21, 2013
Last Verified: April 2013