Clinical Trial: Flow MRI in Normal Pressure Hydrocephalus

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Benefit of Flow Magnetic Resonance Imaging in the Management of Normal Pressure Hydrocephalus

Brief Summary: Normal pressure hydrocephalus diagnosis based on quantitative study of cerebro-spinal fluid and blood flow by phase contrast magnetic resonance imaging.

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire, Amiens

Current Primary Outcome: cerebrospinal fluid (CSF) stroke volume evolution other 6 months [ Time Frame: Day 1 (baseline), Day 180 ]

Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Blood flow analysis : evolution other 6 months [ Time Frame: Day 1 (baseline), Day 180 ]
    Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution.
  • Larson's score evolution over 6 months [ Time Frame: Day 1, Day 180 ]
    Record symptoms on walking, living conditions and urinary disorders
  • Neuropsychological test evolution over 6 months [ Time Frame: Day1, Day 180 ]
    Consists in mini mental status evaluation (MMSE) for cognitive evaluation
  • Blood flow analysis : evolution other one year [ Time Frame: Day 1 (baseline) and Day 365 ]
    Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution.
  • Larson's score evolution over one year [ Time Frame: Day 1 and Day 365 ]
    Record symptoms on walking, living conditions and urinary disorders
  • Neuropsychological test evolution over one year [ Time Frame: Day1, Day 365 ]
    Consists in mini mental status evaluation (MMSE) for cognitive evaluation
  • cerebrospinal fluid (CSF) stroke volume evolution other one year [ Time Frame: Day1 (baseline), Day 365 ]
    Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution


Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire, Amiens

Dates:
Date Received: May 24, 2013
Date Started: June 2012
Date Completion: February 2017
Last Updated: November 10, 2016
Last Verified: November 2016