Clinical Trial: Magnetic Resonance Elastography in Hydrocephalus

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Magnetic Resonance Elastography in Hydrocephalus

Brief Summary: The purpose of this project is to assess the utility of a new magnetic resonance technique called magnetic resonance elastography (MRE) in the non-invasive diagnosis of normal pressure hydrocephalus. The investigators hypothesize that MRE produces a unique imaging signature for hydrocephalus that distinguishes the disease from the normal (non-hydrocephalic) but atrophied brain, a distinction not possible with conventional MR imaging studies that are presently available.

Detailed Summary:
Sponsor: Dartmouth-Hitchcock Medical Center

Current Primary Outcome: The primary outcome measure will be mean shear modulus determined from pre-operative (and pre-drain placement) MRE in patients who demonstrate clinical improvement with trial CSF drainage versus patients who do not demonstrate improvement. [ Time Frame: 15 Years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Pre-operative (and pre-drain placement) shear modulus in the experimental group will be compared with various assessments of clinical improvement after VP shunting. [ Time Frame: 15 Years ]

Secondary outcomes will compare pre- and post-drain MRE shear moduli with ventricular size and intracranial pressure.


Original Secondary Outcome: Same as current

Information By: Dartmouth-Hitchcock Medical Center

Dates:
Date Received: August 28, 2014
Date Started: December 2004
Date Completion:
Last Updated: September 2, 2014
Last Verified: August 2014