Clinical Trial: Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome
Brief Summary: To research the effect of vitamin A to newborn respiratory distress syndrome by intratracheal administration with surfactant.
Detailed Summary: Chronic lung disease (CLD) of prematurity is the major cause of long-term disability of extremely LBW (ELBW) premature infants, and it is the most cost consumptive disease in Neonatal Intensive Care Unit graduates. Vitamin A plays an important role in the development of premature lung. Nevertheless, premature infants are prone to vitamin A deficiency. Oral supplementation of vitamin A does not alter the incidence of CLD in ELBW infants. Intramuscular administration of vitamin A reduced the incidence of CLD. The treatment is considered painful and this way is not routinely practiced. Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress.
Sponsor: Third Military Medical University
Current Primary Outcome: Intratracheal Vitamin A Administration with Surfactant for Newborn Respiratory Distress Syndrome [ Time Frame: 1 year ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Overall clinical outcomes at Newborn Infants With Respiratory Distress Syndrome [ Time Frame: 13 months ]
Original Secondary Outcome: Same as current
Information By: Third Military Medical University
Dates:
Date Received: December 3, 2010
Date Started: January 2012
Date Completion: December 2013
Last Updated: July 25, 2011
Last Verified: November 2010