Clinical Trial: Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome

Brief Summary: Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells. Increasing evidence has demonstrated that these lung disorders might be an important cause of neonatal respiratory distress syndrome (NRDS) by influencing gas exchange or surfactant function, particularly in near-term and term infants. The SCNN1A gene, which encodes the α-ENaC, might predispose infants to NRDS. To explore whether the single-nucleotide polymorphisms (SNPs) of SCNN1A are associated with NRDS, we conducted a case-control study to investigate the NRDS-associated loci in Han Chinese infants. Seven target SNPs were selected from the SCNN1A gene and were genotyped using the improved multiplex ligase detection reaction (iMLDR).

Detailed Summary:
Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Current Primary Outcome: Genotype distributions of target SNPs in RDS group and Control group [ Time Frame: within 28 days after birth ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Dates:
Date Received: January 3, 2015
Date Started: January 2012
Date Completion:
Last Updated: January 6, 2015
Last Verified: January 2015