Clinical Trial: Study on the Effect of NdYag Laser for the Treatment of Hidradenitis Suppurativa

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Prospective Controlled Study of the Efficacy of NdYag for Hidradenitis Suppurativa

Brief Summary:

  • Determination of the short and long term efficacy of NdYag laser for treatment of Hidradenitis suppurativa, which is an inflamed, deeper follicular disorders.
  • Determination of patient tolerance of discomfort associated with NdYag laser treatment for Hidradenitis suppurativa.
  • Determination of the impact of this condition on quality of life and if there is any impact of therapy in the dermatology quality of life index.
  • Evaluate the histopathologic changes of YAG therapy on affected skin

Second phase of study:

  • Prospective, controlled clinical and histologic study of patients with Hurley Stage II HS disease.
  • 19 patients of skin types II to VI with Hurley Stage II hidradenitis suppurativa lesions of the axilla and groin. This is a different set of patients than those treated in the first phase of the study above. This study primarily focuses on and further characterizes the histologic changes after laser treatment.

Detailed Summary:

  1. Background:

    Hidradenitis suppurativa (HS) is a chronic suppurative recurrent disease of the apocrine glands. Histological studies suggest that it is a disease of the follicles with apocrine involvement as a secondary event. There is limited efficacy of medical treatments and high morbidity for surgical treatment. Limited data are available on the short and long term efficacy of laser treatments for use in HS.

  2. Purpose of the study:

    To investigate the efficacy of NdYag 1064nm laser for the treatment of hidradenitis suppurativa.

  3. Significance:

    Hidradenitis suppurativa is a chronic, often suppurative skin condition which affects primarily the hair follicles. A variety of therapies have been used to treat HS, often with unsatisfactory results. As the Nd Yag laser is a highly effective laser treatment for hair removal as well as for the treatment of deeper follicular disorders of the skin which associated inflammation, we postulate that the Nd Yag may be highly effective for decreasing the inflammation, pain, suppuration and frequency of recurrence of HS.

  4. Study design:

    • we are treating patients with HS Hurley Stage II on one side of the body with long-pulsed Nd:YAG laser.
    • The control is the patient's opposite symmetrical side of the body.
    • Pre-treatment assessment is performed along the Hidradenitis
      Sponsor: Henry Ford Health System

      Current Primary Outcome:

      • We will be measuring patients' response by the clinical scoring criteria of the Hidradenitis Suppurativa European Research Group (HISERG) scale. [ Time Frame: 6 months ]
      • Examining histologic changes at various time points following 1064 nm Nd:YAG laser treatment of hidradenitis suppurativa. [ Time Frame: 6 months. ]


      Original Primary Outcome: We will be measuring patients' response by the clinical scoring criteria of the Hidradenitis Suppurativa European Research Group (HISERG) scale. [ Time Frame: 6 months ]

      Current Secondary Outcome: Completion of a post treatment survey regarding the pain of the treatment, pain of their skin condition after treatment, frequency of breakouts, effectiveness of treatment, overall level of satisfaction, likelihood to use the treatment again. [ Time Frame: Monthly, through 6 months ]

      Original Secondary Outcome: Completion of a post treatment survey regarding the pain of the treatment, pain of their skin condition after treatment, frequency of breakouts, effectiveness of treatment, overall level of satisfaction, likelihood to use the treatment again. [ Time Frame: At the end of laser sessions. ]

      Information By: Henry Ford Health System

      Dates:
      Date Received: June 27, 2007
      Date Started: June 2007
      Date Completion:
      Last Updated: May 20, 2010
      Last Verified: May 2010