Clinical Trial: Methylprednisolone Replacement for Dexamethasone-induced Hiccup

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional

Official Title: Pilot Study of Methylprednisolone Replacement for Dexamethasone-induced Hiuup Patients

Brief Summary:

Dexamethasone is a potent synthetic member of the corticosteroid. It is given to cancer patients undergoing chemotherapy to counteract emetic side effect and essential drug for the chemotherapy-treated patients. Hiccup is common adverse effect of corticosteroid especially on dexamethasone varying from 3% to 60% of given patients. Discontinuance of dexamethasone relieves most hiccupping cases, but vomiting/nausea rates increase. It is not clear whether hiccup side effect is limited to the dexamethasone only or other corticosteroid group.

Methylprednisolone, synthetic corticosteroid as similar as dexamethasone, could be considered as antiemetic agent for the patients with receiving chemotherapy. The investigators perform this pilot study under hypothesis that replacing dexamethasone with methylprednisolone could maintain antiemetic role and prevent hiccup.


Detailed Summary:
Sponsor: Gyeongsang National University Hospital

Current Primary Outcome: Prevention rate of dexamethasone induced hiccup [ Time Frame: 24hrs after chemotherapy ]

measure the presence of hiccup and its severity 24 hous after chemotherapy


Original Primary Outcome: Same as current

Current Secondary Outcome: Prevention rate of nausea and vomiting [ Time Frame: acute; 24 hours, delayed; 7 days after chemotherapy ]

Prevention rate of nausea and vomiting 24 hours and 7 days after chemotherapy, respectively


Original Secondary Outcome: Same as current

Information By: Gyeongsang National University Hospital

Dates:
Date Received: January 13, 2011
Date Started: July 2010
Date Completion: December 2011
Last Updated: November 18, 2012
Last Verified: November 2012