Clinical Trial: Economic Evaluation Comparing CCT With MMT in Hai Phong City, Vietnam

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Economic Evaluation Comparing Center-based Compulsory Drug Treatment With Community-based Methadone Maintenance Treatment in Hai Phong City, Vietnam

Brief Summary: The study compared the effectiveness and cost-effectiveness of two dominant heroin dependence treatment approaches: center-based compulsory rehabilitation (CCT) and community-based voluntary methadone treatment (MMT) in Hai Phong City, Vietnam. The design was a combined retrospective and prospective, non-randomized cohort over three years (with data at five time-points). The study was conducted between 2012 and 2015, involving 208 CCT participants and 384 MMT participants with heroin dependence.

Detailed Summary:

The study compared the effectiveness and cost-effectiveness of two dominant heroin dependence treatment approaches: center-based compulsory rehabilitation (CCT) and community-based voluntary methadone treatment (MMT) in Hai Phong City, Vietnam. CCT centers are institutions in which people who use drugs are confined for two years. MMT has been internationally recognized as an efficacious treatment for heroin dependence and was introduced in Vietnam in 2008.

The design was combined retrospective and prospective, non-randomized cohort over three years (with data at five time-points). The study was conducted between 2012 and 2014, involving 208 CCT participants (of which 80% were followed up) and 384 MMT participants (of which 78% were followed up) with heroin dependence. The five time-points were: baseline, two years after treatment commencement, then three months, six months and 12 months after the initial two years. The study combined primary data and secondary data to assess the effectiveness of the two treatment modalities. The economic component measured the costs of the two treatment modalities to compare cost-effectiveness outcomes.

The study had two primary outcomes: self-reported heroin abstinence (confirmed by urine drug screening) and self-reported drug-free days (DFDs). DFDs was reported in two different time-frames. DFDs in the preceding 30 days was used for effectiveness comparison and DFDs over three years was used for the cost-effectiveness comparison. The study has four secondary outcomes: illegal behaviors, overdose, blood-borne virus (BBV) risk behaviors, and monthly drug spending).

Mixed effects regression models were used to analyze the effectiveness data and non-parametric bootstrapping methods were used to estimate cost-effectiveness. The time-frame for
Sponsor: The University of New South Wales

Current Primary Outcome: Heroin abstinence [ Time Frame: Preceding 3 months and 30 days ]

Free from heroin use (self-reported), confirmed by urine drug screening on interview day.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Drug-free days [ Time Frame: Preceding 3 months and 30 days ]
    Days without use of any illicit drugs (self-report)
  • Drug-use related illegal behaviors [ Time Frame: Preceding 3 months and 30 days ]
    Drug-use related illegal behaviors
  • Drug-use related blood-borne virus (BBV) risk behaviors [ Time Frame: Preceding 3 months and 30 days ]
    Drug-use related blood-borne virus (BBV) risk behaviors
  • Overdose incidents [ Time Frame: Preceding 3 months and 30 days ]
    Overdose incidents
  • Monthly drug spending [ Time Frame: Preceding 3 months and 30 days ]
    Monthly drug spending


Original Secondary Outcome: Same as current

Information By: The University of New South Wales

Dates:
Date Received: February 28, 2017
Date Started: January 20, 2013
Date Completion:
Last Updated: March 9, 2017
Last Verified: March 2017