Clinical Trial: Initiation of Resuscitation While Attached to the Cord With Congenital Diaphragmatic Hernia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Initiation of Resuscitative Care While on Placental Circulation for Infants With Congenital Diaphragmatic Hernia - a Randomized Pilot Trial

Brief Summary:

This study aims to measure the cardio-respiratory physiological consequences of initiating resuscitation during placental transfusion (PT) with an intact umbilical cord in infants with congenital diaphragmatic hernia (CDH). PT, mainly via delayed cord clamping, has been shown to offer a higher circulating blood volume, less need for blood transfusion, less need for inotropes in infants.

Currently infants with CDH receive immediate cord clamping (ICC) to facilitate immediate resuscitation including immediate intubation and mechanical ventilation.

With the development of a resuscitation platform (iNSPiRE), resuscitative care can now be commenced from birth in infants with CDH to benefit from PT.


Detailed Summary:
Sponsor: University of Alberta

Current Primary Outcome: Proportion of infants with hypotension requiring inotropes [ Time Frame: first 24 hours after birth ]

Proportion of infants with hypotension requiring inotropes in the first 24 hours after birth in the neonatal intensive care unit.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Alberta

Dates:
Date Received: March 17, 2017
Date Started: April 27, 2017
Date Completion: August 31, 2018
Last Updated: April 27, 2017
Last Verified: March 2017