Clinical Trial: The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage?

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage?

Brief Summary: The Cerebral Amyloid angiopathy (CAA) is the leading cause of cortical hemorrhage after 65 years. The presence of cerebral infarction is also reported anatomically in the AAC. MRI studies of these infarcts are rare. They are described as punctate, cortical silent. Frequency and pathophysiology is poorly understood. The investigators put the question of a link with hemorrhagic lesions of the AAC.

Detailed Summary:

Main objective / secondary

The objectives are:

  • To assess frequency of cortical infarcts in the cohort of patients recruited consecutively likely AAFC GHPSJ since 2007
  • To assess the link between the presence of myocardial infarction and the clinical characteristics of patients and
  • To study the relationship between topography and the brain hemorrhage one hand, meningeal hemorrhage other.

Inclusion / exclusion Any patient who was diagnosed as carrying a probable AAC according to the Boston criteria and has had a brain MRI with the following sequences: classic or enhanced diffusion (or DTI B2000), T1, T2 FLAIR, T2EG (T2 * or SWAN)

Methodology This is a non-interventional study single center, including AAC patients hospitalized in the Hospital Group Paris Saint-Joseph from May 2007 to May 2014.

Clinical patient characteristics were collected from their medical records. Patients are aware of the potential use of their data for medical research by information contained in the handbook of the institution.

Brain MRI will be proofread by a neurologist and a neuroradiologist to clarify:

  • the number and location of myocardial puncture
  • the number and location of macro-bleeding
  • the number of microbleeds (micro-bleeding)
  • the presence and location of subarachnoid hemorrhage and / or hemosiderosis
  • the location of the pu
    Sponsor: Groupe Hospitalier Paris Saint Joseph

    Current Primary Outcome:

    • the number and location of myocardial puncture [ Time Frame: Day 1 ]
    • the number and location of macro-bleeding [ Time Frame: Day 1 ]
    • the number of microbleeds (micro-bleeding) [ Time Frame: Day 1 ]
    • the presence and location of subarachnoid hemorrhage and / or hemosiderosis [ Time Frame: Day 1 ]
    • the location of the puncture infarction [ Time Frame: Day 1 ]
      the location of the puncture infarction compared to macro-hemorrhage and subarachnoid hemorrhage / hemosiderosis: ipsilateral <5cm, ipsilateral> 5cm, another location


    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    Original Secondary Outcome:

    Information By: Groupe Hospitalier Paris Saint Joseph

    Dates:
    Date Received: July 13, 2016
    Date Started: June 2014
    Date Completion:
    Last Updated: July 18, 2016
    Last Verified: July 2016