Clinical Trial: Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer

Brief Summary: The purpose of this study is to determine proportion of patients presented a search allelic imbalance of expression of genes BRCA 1 and 2 in population with hereditary breast and/or ovarian cancer risk and negative for deletion mutation BRCA 1 and 2 genes

Detailed Summary:
Sponsor: Centre Francois Baclesse

Current Primary Outcome: estimate the proportion of patients with allelic imbalance at the level of expression of BRCA1 [ Time Frame: blood sample at baseline, no follow-up in this study ]

The main objective of this study is to estimate the proportion of patients with allelic imbalance at the level of expression of BRCA1 in a population meeting the criteria suggestive of a hereditary predisposition to breast and / or ovarian cancer , and negative for deleterious mutations of BRCA 1 and BRCA 2.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Study the variability of the measurement of the allelic expression depending on the position of SNPs [ Time Frame: blood sample at baseline, no follow-up in this study ]
    Study the variability of the measurement of the allelic expression depending on the position of SNPs (Single Nucleotide Polymorphism) in the gene, in order to extend this research to variants of unknown significance whatever their position in the gene.
  • proportion of patients with allelic imbalance at the level of expression of the BRCA2 gene [ Time Frame: blood sample at baseline, no follow-up in this study ]
    Estimate the proportion of patients with allelic imbalance at the level of expression of the BRCA2 gene in the same population.
  • Observe the possible effect of age [ Time Frame: blood sample at baseline, no follow-up in this study ]
    The frequency of allelic imbalance of expression will be compared depending on the age of the witnesses in the control population. The potential effect of age on the presence or absence of allelic imbalance of expression will be observed.


Original Secondary Outcome: Same as current

Information By: Centre Francois Baclesse

Dates:
Date Received: April 4, 2011
Date Started: April 2010
Date Completion:
Last Updated: July 12, 2012
Last Verified: July 2012