Clinical Trial: Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study.

Brief Summary:

Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 < 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation…).

The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.


Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome: Postoperative complication rates in hepatic transplant patients with or without hepatopulmonary syndrome [ Time Frame: 1 year post liver transplantation ]

Collection of medical (cardiac, pulmonary, renal, infectious, neurological) and Surgical (vascular, digestive) complications in hepatic transplant patients with or without hepatopulmonary syndrome


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Length of Mechanical Ventilation [ Time Frame: 1 year post liver transplantation ]
  • Length of ICU stay [ Time Frame: 1 year post liver transplantation ]
  • Length of Hospital Stay [ Time Frame: 1 year post liver transplantation ]
  • Delay of hepatopulmonary syndrome resolution [ Time Frame: 1 year post liver transplantation ]


Original Secondary Outcome: Same as current

Information By: Hospices Civils de Lyon

Dates:
Date Received: March 20, 2017
Date Started: October 1, 2015
Date Completion: March 31, 2017
Last Updated: March 27, 2017
Last Verified: March 2017