Clinical Trial: Alcohol Diet and Drug Use Preceding Alcoholic Hepatitis

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Alcohol Diet and Drug Use Preceding Alcoholic Hepatitis

Brief Summary:

ADDUP is an observational study of patients with alcoholic hepatitis. A structured interview is used to quantitatively estimate:

  1. Alcohol use
  2. Dietary intake
  3. Drug use (legal and illegal)

in the weeks preceding onset of acute alcoholic hepatitis. After interview patients are followed up for 12 months with regard to response to therapy and survival.

The study is intended to explore potential precipitants of alcoholic hepatitis.


Detailed Summary:
Sponsor: University Hospital Birmingham

Current Primary Outcome: Changes in alcohol intake, dietary intake or drug use before illness [ Time Frame: 1 month ]

Behavior before admission (Brief structured interview)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Survival after admission (Brief structured interview) [ Time Frame: 12 months ]
    Survival
  • Response to treatment (Brief structured interview) [ Time Frame: 1 week ]
    Response to treatment (corticosteroids, pentoxifylline or supportive medical care) after 1 week, measured by Lille score


Original Secondary Outcome: Same as current

Information By: University Hospital Birmingham

Dates:
Date Received: March 26, 2015
Date Started: January 2012
Date Completion: January 2018
Last Updated: April 6, 2017
Last Verified: April 2017