Clinical Trial: Pentoxifylline for Acute Alcoholic Hepatitis (AAH)

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: A Pilot Study of Pentoxifylline-Therapy for Acute Alcoholic Hepatitis

Brief Summary: The goal of this study is to demonstrate the effectiveness of pentoxifylline compared to placebo in AAH while studying putative mechanisms that are plausible and testable. The main hypothesis is that pentoxifylline reduces the 90-day mortality of AAH.

Detailed Summary:

The goal of this study is to demonstrate the effectiveness of pentoxifylline compared to placebo in AAH while studying putative mechanisms that are plausible and testable. The main hypothesis is that pentoxifylline reduces the 90-day mortality of AAH.

This study never moved forward due to funding issues.

Sponsor: University of Wisconsin, Madison

Current Primary Outcome: Survival at 28 Days [ Time Frame: 28 days ]

Original Primary Outcome: Survival at 90 days

Current Secondary Outcome:

Original Secondary Outcome: Survival at 28 days; the effect of pentoxifylline on circulating TNF, oxidative stress and renal function

Information By: University of Wisconsin, Madison

Dates:
Date Received: September 13, 2005
Date Started: March 2005
Date Completion:
Last Updated: April 10, 2014
Last Verified: April 2014