Clinical Trial: Intrapleural Urokinase for Retained Hemothorax

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Intrapleural Thrombolytic Treatment With Urokinase for Retained Hemothorax: A Prospective Double-blinded Randomized Multicenter Study

Brief Summary: Intrapleural thrombolytic treatment with urokinase for retained hemothorax is effective and safe. However, previous study was limited in prospective observation study without control group.

Detailed Summary: We will recruit 32 patients in this study. The patients with retained hemothorax will be randomly divided into the urokinase group and the placebo group. In the urokinase group, urokinase 100,000 IU in 100 mL NaCl will be injected into the intrapleural space. We will record the daily drainage amount and evaluate the therapeutic effect by the chest X-ray. The therapeutic effect, safety, hospital stay, and medical cost between the two groups will be compared. This study will be done in four medical centers in northern Taiwan.
Sponsor: National Taiwan University Hospital

Current Primary Outcome: non-surgical rate [ Time Frame: about 5 days ]

Complete response and partial response


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: National Taiwan University Hospital

Dates:
Date Received: May 27, 2010
Date Started: May 2010
Date Completion: August 2013
Last Updated: May 28, 2010
Last Verified: May 2010