Clinical Trial: Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis in a North-American Tertiary Center at the Beginning of the 21st Century

Brief Summary: The study consist of a retrospective analysis of the etiologies, investigations and outcomes of patients presenting between 2005 to 2010 with hemoptysis in a North-American Tertiary center.

Detailed Summary:

RATIONALE:

Hemoptysis, mild or massive, is worrisome for both patients and physicians. The management is different depending on the causes, which are not well defined for the North American population. Despite the fact that this symptom is commonly reported in clinic, there are only a few studies published on this subject in the North-American population. Tuberculosis was a frequent cause of hemoptysis described in populations overseas, which seems less prevalent in the investigators center.

Also, there are no known official guidelines regarding the investigation and management of hemoptysis. The investigators hypothesized that the use of modern technology in a North American population may result in different findings and provide a more accurate diagnostic approach.

Therefore, the study compares the different etiologies of hemoptysis and investigation modalities used in patients presenting in a North-American tertiary center.

METHOD:

The investigators did a retrospective analysis of medical chart from patients with hemoptysis who visited the investigators center between 2005 and 2010. Each visit has been reviewed individually to describe the characteristics of patients, etiologies of hemoptysis and investigation modalities used. All-cause mortality at 2 years was also recorded.

Descriptive statistical analyses will conducted on the data available.


Sponsor: Université de Sherbrooke

Current Primary Outcome: Etiologies of hemoptysis [ Time Frame: 5 years ]

Defining the prevalence of pulmonary diseases by measuring the percentage of patients presenting with hemoptysis caused by lung cancer, bronchiectasis, pulmonary embolism, arteriovenous fistula, pneumonia, bronchitis, tuberculosis, mycosis, heart failure, pseudohemoptysis, cryptogenic and other causes.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Sensitivity of chest X-ray, chest CT-scan and CT-angiography, bronchoscopy, ventilation-perfusion with single-photon emission computed tomography and pulmonary angiography. [ Time Frame: 5 years ]
    Determining the sensitivity in obtaining the etiology of the hemoptysis episode of each diagnostic modality that follows : chest X-ray, chest CT-scan and CT-angiography, bronchoscopy, ventilation-perfusion with single-photon emission computed tomography and pulmonary angiography in the diagnosis of different etiologies of hemoptysis.
  • All-cause mortality at 2 years [ Time Frame: 2 years ]
    All-cause mortality at 2 years after the diagnosis of hemoptysis.
  • Smoking status [ Time Frame: Day 1 ]
    Determining the percentage of patients who : never smoked, is an active smoker, former smoker or unknown status.
  • Age [ Time Frame: Day 1 ]
    Determining the average age of the enrolled patients.
  • Gender [ Time Frame: Day 1 ]
    Determining the percentage of each gender of the enrolled patients.
  • International Normalized Ratio [ Time Frame: Day 1 ]
    Determining the median of the international normalized ratio (INR).
  • Partial Thromboplastin Time [ Time Frame: Day 1 ]
    Determining the median of the partial thromboplastin time (PTT).
  • Platelet count [ Time Frame: Day 1 ]
    Determining the average of the platelet count measured per microliter of blood.


Original Secondary Outcome: Same as current

Information By: Université de Sherbrooke

Dates:
Date Received: September 15, 2016
Date Started: October 2012
Date Completion: June 2017
Last Updated: September 22, 2016
Last Verified: September 2016