Clinical Trial: Efficacy of Tranexamic Acid in Hemoptysis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Efficacy of Tranexamic Acid in Controlling Hemoptysis, A Randomized Control Trial

Brief Summary: The purpose of study is to evaluate the efficacy of tranexamic acid in controlling bleeding in patients of hemoptysis and also to evaluate the safety of tranexamic acid.

Detailed Summary: Hemoptysis is a common problem in India due to high incidence of tuberculosis and also due to post tubercular sequale. Hemoptysis is usually managed conservatively in mild to moderate cases and cases of massive hemoptysis are managed with more definitive treatment options like vessel embolization (bronchial/pulmonary artery) and surgery as a last option. Tranexamic acid is a antifibrinolytic used in many surgeries and trauma patients to control bleeding and it has been shown effective and safe. The purpose of the study is to evaluate the efficacy of tranexamic acid in patients with hemoptysis in controlling bleeding.
Sponsor: Postgraduate Institute of Medical Education and Research

Current Primary Outcome: Change in severity of hemoptysis [ Time Frame: day1 and day2 ]

Frequency, amount, VAS score Objective assessment using VAS score at admission and at 48 hours.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Intervention needed [ Time Frame: 2 days ]
    Whether intervention needed to control hemoptysis, in the form of bronchial/pulmonary artery embolization or surgery.(Yes/No)
  • Blood transfusion needed [ Time Frame: 2 days ]
    Number of blood transfused
  • Hospital stay [ Time Frame: Through study completion, an average of 1 year ]
    Number of days of hospital stay


Original Secondary Outcome: Same as current

Information By: Postgraduate Institute of Medical Education and Research

Dates:
Date Received: April 17, 2016
Date Started: January 2011
Date Completion:
Last Updated: May 20, 2016
Last Verified: May 2016