Clinical Trial: Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Patients With PNH

Brief Summary: Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder in which unregulated activation of the complement system leads to significant ischemic morbidities with shortened lifespan. Life-threatening thromboembolism (TE) is the most feared complication of PNH, accounting for up to 45% of patient deaths. It is estimated that 40% of PNH patients experience a clinically evident TE and 60% of patients without clinically diagnosed TE demonstrate TE by high-sensitivity MRI, indicating the ongoing thrombotic risk in most patients with PNH. Much of these data come from PNH patients from European descent. To understand the impact of TE in patients with PNH from non-European regions, we performed this study to evaluate the clinical characteristics of Korean patients with PNH.

Detailed Summary: To evaluate the clinical characteristics in Korean PNH patients
Sponsor: Samsung Medical Center

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Samsung Medical Center

Dates:
Date Received: October 18, 2010
Date Started: August 2010
Date Completion: December 2010
Last Updated: October 19, 2010
Last Verified: October 2010