Clinical Trial: Bone Status on Patients With Genetic Hemochromatosis: a 3 Years Descriptive and Evolutionary Study

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Bone Status on Patients With Genetic Hemochromatosis : a 3 Years Descriptive and Evolutionary Study.

Brief Summary: The purpose of this study is to describe bone status on patients with genetic hemochromatosis, at diagnostic time and his evolution under treatment.

Detailed Summary: Bone diseases have been recognized recently as complications of genetic hemochromatosis. Further studies are needed to describe the role of iron in bone injuries. The purpose of this study is to describe bone status on patients with genetical hemochromatosis, at diagnostic time and his evolution under treatment.
Sponsor: Rennes University Hospital

Current Primary Outcome: Bone mineral density [ Time Frame: Change from baseline in bone mineral density at three years ]

Vertebral and hips Dual energy X-ray Absorptiometry (DXA)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Predictive value of iron overload on Bone Mineral Density [ Time Frame: 1 day ]
  • Number of vertebral fractures [ Time Frame: 3 years ]
  • Number of peripheral fractures [ Time Frame: 3 years ]
  • Number and location of joint lesions detected by the examination (pain and swelling) [ Time Frame: 3 years ]
  • Determination of genetic polymorphism of BMP 2 and 4 [ Time Frame: Baseline ]


Original Secondary Outcome: Same as current

Information By: Rennes University Hospital

Dates:
Date Received: March 1, 2012
Date Started: July 2008
Date Completion:
Last Updated: May 26, 2015
Last Verified: May 2015