Clinical Trial: Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone

Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational

Official Title: Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone: Evaluation Using Micro CT 3D High Resolution and by Magnetic Resonance Imaging (MRI)

Brief Summary: In hemiplegic, there is very little data on the impact of neurological deficit on the microarchitecture independent of bone mineral density and composition of the bone marrow. Rare studies have shown the relationship between some micro-architectural parameters and severity of neurological deficit. There is no study in humans on the evolution of the parameters of the microarchitecture assessed by 3D micro-tomography in the early phase of the installation of neurological deficits after stroke, in terms of a bearing bone, tibia, that a non-load bearing bones, radius.

Detailed Summary: Each patient must answer several questionnaires about their calcium intake and its ability to perform everyday tasks. They will also have 3 blood samples (15 ml each time), 3 measure of bone by 3D micro-tomography and 2 MRI examination. These examinations and sampling will take place after 30 days after stroke onset (except for MRI) and again after three months and six months after the stroke (the same day as the medical follow-up visit).
Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Current Primary Outcome: Bone volume / tissue volume [ Time Frame: 90 days ]

Measure of Bone volume / tissue volume by the 3D CT scan


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Bone volume / tissue volume [ Time Frame: 1 day ]
    Measure of Bone volume / tissue volume by the 3D CT scan
  • intraosseous fat [ Time Frame: 90 days ]
    Measure the percentage of the intraosseous fat by MRI


Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire de Saint Etienne

Dates:
Date Received: September 7, 2015
Date Started: June 2009
Date Completion:
Last Updated: September 8, 2015
Last Verified: September 2015