Clinical Trial: Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm

Brief Summary: The purpose of this study is to determine whether pretarsal and preseptal techniques of Botulinum toxin type A injection have any effect on tear functions.

Detailed Summary: Botulinum toxin type A has been used for hemifacial spasm since 1986. of Botulinum toxin type A can be subcutaneously injected at pretarsal or preseptal portion of orbicularis muscle. Blepharoptosis has been reported less frequently with pretarsal technique, however dry eye was noticed in one patient treated with pretarsal botulinum toxin type A for cosmetic purpose.
Sponsor: Khon Kaen University

Current Primary Outcome: tear break up time [ Time Frame: change from baseline in tear break up time at 12 weeks ]

unit of measure; minutes


Original Primary Outcome: Same as current

Current Secondary Outcome: schirmer's test [ Time Frame: change from baseline of schirmer's test at 12 weeks ]

units of measurement; millimeters


Original Secondary Outcome: Same as current

Information By: Khon Kaen University

Dates:
Date Received: March 18, 2012
Date Started: April 2012
Date Completion: December 2012
Last Updated: March 27, 2012
Last Verified: March 2012