Clinical Trial: Management of Soil-transmitted Helminthiasis and Strongyloidiasis
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Community-based Approach for the Management of Soil-transmitted Helminthiasis in General and Strongyloidiasis in Particular in a Highly Endemic Area
Brief Summary: The general purpose of the project is to analyse soil-transmitted helminthiases (STH) in a highly endemic area in northern Argentina with a multidisciplinary approach. The specific objectives are to evaluate the local epidemiology of STH, validate a new diagnostic serology method for S. stercoralis and evaluate the efficacy and safety of a mass drug administration regimen with albendazole and ivermectin.
Detailed Summary:
Sponsor: Universidad Nacional de Salta
Current Primary Outcome: Evaluation of local epidemiology of soil-transmitted helminthiases and impact of a mass drug treatment anti-helminthic strategy [ Time Frame: 15 months ]
Evaluate local epidemiology of STH: frequency of species, prevalence and intensity of infections, groups more affected, morbidity.
Evaluate the efficacy of a single-dose anti-helminthic regimen for community treatments: albendazole 400 mg + ivermectin 200 mcg/kg.
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Validate serology methods for diagnosis of S. stercoralis infection [ Time Frame: 15 months ]Compare sensibility, specificity and predictive values of serology for S.stercoralis (ELISA-NIE) with traditional coproparasitological methods
- Assess the tolerability and safety of the combination of ivermectin and albendazole [ Time Frame: 15 months ]
Original Secondary Outcome: Same as current
Information By: Universidad Nacional de Salta
Dates:
Date Received: March 3, 2011
Date Started: December 2010
Date Completion: April 2012
Last Updated: March 3, 2011
Last Verified: February 2011
