Clinical Trial: Exertional Heat Illness: Biomarkers for Prediction and Return to Duty

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title:

Brief Summary: The investigators goal is to monitor and quantify the differential physiologic and biomarker responses of controls to standardized exercise under thermoneutral and thermally challenged conditions and responses of exertional heat stroke (EHS) subjects under a thermal-challenged environment to develop unique bio-signature panels to predict those at risk for exertional heat illness (EHI) and guide return to duty following an episode of EHS.

Detailed Summary:
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine

Current Primary Outcome:

  • Heat tolerance [ Time Frame: 2-hour heat test ]
    Heat tolerance is determined by physiologic response to a 2-hour heat tolerance test. During this test, participants with core temperature greater than 38.5 C and/or heart rate greater than 150 bpm are considered heat intolerant.
  • Genetic response to heat tolerance [ Time Frame: 2-hour heat heat tolerance test ]
    DNA microarray will be conducted to see whether certain genes can predict response to the heat. Likewise, RNA microarray of RNA expression pre- and post-heat test will be conducted to further determine genetic pathways of heat intolerance.


Original Primary Outcome:

Current Secondary Outcome:

  • Fitness [ Time Frame: 2-hour heat tolerance test ]
    Body fat and aerobic capacity will be measured to quantify their contribution to heat tolerance.
  • Behavioral correlates of heat tolerance [ Time Frame: past month ]
    Questionnaires will be used to assess behavioral correlates of heat tolerance, including measures of sleep impairment and executive dysfunction.
  • Perceived heat strain [ Time Frame: 2-hour heat tolerance test and 2-hour control test ]
    Measures of perceived heat strain will be recorded to determine how accurately participants perceive that they are working in the heat, and whether this adds diagnostic value to the heat test.


Original Secondary Outcome:

Information By: Henry M. Jackson Foundation for the Advancement of Military Medicine

Dates:
Date Received: September 14, 2011
Date Started: July 2011
Date Completion:
Last Updated: January 6, 2015
Last Verified: January 2015