Clinical Trial: Radiation Induced Cardiopulmonary Injury in Humans
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Radiation Induced Cardiopulmonary Injury in Humans
Brief Summary: The purpose of the study is to assess the time, dose dependence, and fraction-size dependence of radiation (RT)-induced changes in regional lung and heart perfusion/function/structure following thoracic RT delivered using newer IMRT/conformal/radiosurgery techniques. The PI hopes to develop models to better relate and predict RT-induced changes in regional lung and heart perfusion/function/structure with changes in global cardiopulmonary function. Patients will undergo pre- and serial post-RT lung and heart assessments to better understand RT-induced regional heart/lung changes.
Detailed Summary:
Sponsor: UNC Lineberger Comprehensive Cancer Center
Current Primary Outcome:
- Changes in Regional Lung Function [ Time Frame: Up to 4 years post CRT ]
- Changes in Regional Heart Function [ Time Frame: Up to 4 years post CRT ]
- Relating RT-Induced Changes in Regional injury to Global Cardiopulmonary Changes [ Time Frame: Up to 4 years post CRT ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: UNC Lineberger Comprehensive Cancer Center
Dates:
Date Received: October 3, 2014
Date Started: June 2008
Date Completion:
Last Updated: January 6, 2017
Last Verified: January 2017
