Clinical Trial: Oxidative Stress and Cardiac Arrest
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Evaluation of Oxidative Stress After Out of Hospital Cardiac Arrest Treated With Moderate Hypothermia
Brief Summary:
Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.
Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.
The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.
Detailed Summary:
Sponsor: Institut d'Anesthesiologie des Alpes Maritimes
Current Primary Outcome: Oxidative stress markers and antioxidants after out of hospital cardiac arrest [ Time Frame: 4 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Lactate after out of hospital cardiac arrest [ Time Frame: 4 days ]
- Outcome after out of hospital cardiac arrest [ Time Frame: 6 months ]
Original Secondary Outcome: Same as current
Information By: Institut d'Anesthesiologie des Alpes Maritimes
Dates:
Date Received: April 25, 2009
Date Started: April 2006
Date Completion:
Last Updated: June 30, 2011
Last Verified: June 2011
