Clinical Trial: Fludrocortisone for Sudden Hearing Loss

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Mineralocorticoid Treatment for Sudden Sensorineural Hearing Loss

Brief Summary: The standard of care treatment of sudden hearing loss uses a type of steroid called glucocorticoid. Examples of glucocorticoids are prednisone, methylprednisolone and dexamethasone. Not everybody recovers hearing with glucocorticoid treatment. Fludrocortisone is a different type of steroid called mineralocorticoid. Unlike glucocorticoids, which work by reducing inflammation, mineralocorticoids work by changing salt and fluid balance. In animal studies, fludrocortisone is at least as effective as glucocorticoid in preserving hearing. Fludrocortisone is not approved for the treatment of sudden hearing loss. The purpose of this study is to test whether fludrocortisone can treat sudden hearing loss.

Detailed Summary:
Sponsor: Oregon Health and Science University

Current Primary Outcome: Hearing [ Time Frame: At one month ]

Hearing outcome will be determine by pure-tone and speech audiometry measured at the completion of a one-month course of treatment and compared with pre-treatment test results.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Oregon Health and Science University

Dates:
Date Received: August 19, 2010
Date Started: August 2012
Date Completion: August 2016
Last Updated: April 21, 2015
Last Verified: April 2015