Clinical Trial: International Ovarian & Testicular Stromal Tumor Registry

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: International Ovarian & Testicular Stromal Tumor Registry

Brief Summary:

Rare tumors are understudied, yet have the potential to shed light on vast areas of cancer research. Ovarian sex cord-stromal tumors, rare tumors of childhood and young adulthood, have recently been found to be associated with a lung cancer of early childhood called pleuropulmonary blastoma (PPB). The cause of these ovarian tumors is unknown. DICER1 mutations are seen in the majority of children with PPB. Research shows DICER1 mutations are also seen in some patients with ovarian tumors. Like PPB, ovarian stromal tumors are highly curable when found in early stage; however, later forms of the disease are aggressive and often fatal. The International Ovarian Stromal Tumor Registry collects clinical and biologic data to understand why these tumors occur and how to treat them. Current work involves the study of the role of DICER1 and miRNA expression in ovarian stromal tumors. Understanding the clinical history, predisposing factors and DICER1 and miRNA expression in these ovarian tumors of childhood will lead to targeted screening and risk stratification for evidence-based treatment and biologically rational therapies. These efforts will improve the lives of children by increasing survival and reducing late effects.

The specific goals of the International Ovarian and Testicular Stromal Tumor Registry are:

  1. to understand risk factors by studying age, pathologic subtype, histopathologic features, tumor invasiveness, degree of differentiation, presence of metastasis
  2. to collect information on personal and family history in order to refine the clinical characteristics of patients and families with and without germline DICER1 mutations and other genetic predisposing factors
  3. to determine whether there is a pattern of gene expression

    Detailed Summary:

    The Registry collects and analyzes case-by-case data on ovarian stromal tumors. Cases are identified:

    1. by referrals from clinicians or pathologists
    2. by families initiating contact with the Registry
    3. by Registry requests to authors of published cases to share further details

    The data collected include:

    1. clinical and laboratory findings
    2. family history
    3. imaging studies
    4. surgery records
    5. pathology records including review and study of pathology materials
    6. treatment (surgery, chemotherapy, radiation)
    7. recurrences or metastases
    8. long-term follow-up

    The demographic and clinical data are abstracted into a database secured by password protection. Each record in the database has a unique Registry number.

    Enrollment in the OTST Registry is based on local diagnosis, but central pathology review is offered as a part of Registry procedures. DICER1 testing is facilitated.

    For each patient enrolled, the Registry will request 1) whole blood for DNA extraction and lymphoblastoid cell line generation 2) slides or snap frozen tumor tissue (if available), and 3) paraffin blocks. In some cases, saliva samples, buccal swabs or urine samples will be obtained for DNA extraction.

    Pathology materials are centrally reviewed when
    Sponsor: Children's Hospitals and Clinics of Minnesota

    Current Primary Outcome: DICER1 mutations in ovarian and testicular stromal tumors [ Time Frame: 3 years ]

    We will analyze germline DNA from patients with gonadal stromal tumors to determine the presence of DICER1 mutations. The tumor tissue will also be sequenced. mRNA and miRNA expression will be analyzed on tumor tissue. Results of the above will be correlated with clinical outcome.


    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    • Clinical factors associated with outcome in ovarian and testicular stromal tumors [ Time Frame: 3 years ]
      We will analyze the clinical records to determine which factors influence prognosis
    • Pathologic and Genetic Correlations [ Time Frame: 3 years ]
      We will correlate the pathologic and genetic data with clinical data to describe factors associated with poor prognosis.


    Original Secondary Outcome:

    • Clinical factors associated with outcome in ovarian and testicular stromal tumors [ Time Frame: 3 years ]
      We will analyze the clinical records to determine which factors influence prognosis
    • Pathologic and Genetic Correlations [ Time Frame: 3 years ]
      We will correlate the pathologic and genetic data with clinical data to describe factors associated with poor prognosis. We will look for targetable mutations for later stage and recurrent tumors.


    Information By: Children's Hospitals and Clinics of Minnesota

    Dates:
    Date Received: October 23, 2013
    Date Started: December 2011
    Date Completion:
    Last Updated: November 1, 2016
    Last Verified: November 2016