Clinical Trial: Early Mechanical Ventilation for Guillain Barré Syndrome
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Efficacy and Safety of Preventive Mechanical Ventilation in Adults With Guillain Barré Syndrome
Brief Summary: The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
Detailed Summary: Hospital acquired pneumonia is a common and severe complication of Guillain Barré Syndrome. Several factors have been recognized as predictors of respiratory failure in adults with Guillain Barré Syndrome. They include a time from disease onset and patient admission of less seven days, inability to lift head, impaired swallowing and a forced vital capacity of less than 60% of predictive value. We reasonned that early mechanical ventilation may prevent aspiration which is likely the main cause of pneumonia in these patients.
Sponsor: University of Versailles
Current Primary Outcome: Rate of hospital acquired pneumonia from randomization to study day 90 [ Time Frame: Day 90 ]
Original Primary Outcome: Rate of hospital acquired pneumonia from randomization to study day 90
Current Secondary Outcome:
- Time on a ventilator [ Time Frame: Day 90 ]
- Intensive care unit lenght of stay [ Time Frame: Day 90 ]
- Hospital length of stay [ Time Frame: Day 90 ]
- Tolerance [ Time Frame: Day 90 ]
Original Secondary Outcome:
- - Time on a ventilator
- - intensive care unit lenght of stay
- - hospital length of stay
- - tolerance
Information By: University of Versailles
Dates:
Date Received: September 10, 2005
Date Started: April 2005
Date Completion:
Last Updated: July 19, 2016
Last Verified: July 2016
