Clinical Trial: International Guillain-Barré Syndrome Outcome Study

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: International GBS Outcome Study (IGOS): A Prospective INC Study on Clinical and Biological Predictors of Disease Course and Outcome in Guillain-Barré Syndrome (GBS).

Brief Summary:

International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barré syndrome (GBS).

The IGOS aims to identify clinical and biological determinants and predictors of disease course and outcome in individual patients with Guillain-Barré syndrome, as early as possible after onset of disease.


Detailed Summary:

GBS is a post-infectious immune-mediated polyradiculoneuropathy with a highly diverse clinical course and outcome despite partially effective forms of treatment(immunoglobulins and plasma exchange). Outcome in patients with GBS has not improved in the last two decades. At present about 10 to 20% of patients remain severely disabled and about 5% die. One explanation for this stagnation is the highly variable clinical course of GBS and the lack of knowledge about the factors that determine the clinical course in individual patients with GBS. GBS may consist of distinct pathogenic subgroups, in which disease onset and progression is influenced by different types of preceding infections, anti-neural antibodies and genetic polymorphisms. Optimal treatment of individual patients may depend on the pathogenesis and clinical severity. Patients with severe forms of GBS may possibly need more intensive treatment to recover. Patients with a milder course that fully recover after standard therapy could suffer from possibly more side effects of more aggressive forms of treatment. This could only be possible if there are prognostic models that accurately predict the clinical course in individual patients. Ideally such models should be based on clinical and biological predictors that are strongly associated with disease course and known as early as possible in the acute phase of illness, when treatment with immunomodulatory therapy is most effective. Prognostic models could help to guide selective trials in specific GBS subtypes. Because of this it will be possible to treat GBS with more effective and more individual therapy.

This study aims to identify clinical and biological determinants and predictors of disease course and outcome in individual patients with Guillain-Barré syndrome, as early as possible after onset of disease. This information will be used to understand the diver
Sponsor: Erasmus Medical Center

Current Primary Outcome: Guillain-Barre Syndrome(GBS) disability score and Medical Research Council(MRC) sumscore [ Time Frame: 1 year ]

Original Primary Outcome: GBS disability score and MRC sumscore [ Time Frame: 1 year ]

Current Secondary Outcome:

  • Overall Neuropathy Limitations Scale (ONLS) [ Time Frame: 1 year ]
  • Fatigue Severity Scale (FSS) [ Time Frame: 1 year ]
  • EurQol EQ-5D Health Questionnaire [ Time Frame: 1 year ]
  • Rasch-built Overall Disability Scale (R-ODS) [ Time Frame: one year ]


Original Secondary Outcome:

  • ONLS questionnaire [ Time Frame: 1 year ]
  • FSS questionnaire [ Time Frame: 1 year ]
  • EurQol questionnaire [ Time Frame: 1 year ]
  • R-ODS questionnaire [ Time Frame: one year ]


Information By: Erasmus Medical Center

Dates:
Date Received: April 20, 2012
Date Started: May 2012
Date Completion: January 2019
Last Updated: January 4, 2017
Last Verified: January 2017