Clinical Trial: Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of Intravenous Immunoglobulin and Plasma Exchange in Treatment of Mechanically Ventilated Children With Guillain Barre Syndrome. A Randomized Study.

Brief Summary: Comparing whether intravenous immune globulin or plasma exchange is superior in treating mechanically ventilated children with Guillain Barre syndrome.

Detailed Summary:

Children with Guillain Barre syndrome (GBS) admitted to PICU at Mansoura University Children Hospital, Mansoura, Egypt with the need for mechanical ventilation were prospectively enrolled in the study.

Cases were diagnosed according to clinical criteria. The decisions to initiate, wean and terminate mechanical ventilation were made independently by the attending consultant in accordance with the unit guidelines.

Outcome variables measured were duration of mechanical ventilation, length of PICU stay and ability to walk unaided 4 weeks after PICU discharge.


Sponsor: Mansoura University Children Hospital

Current Primary Outcome: Duration of mechanical ventilation [ Time Frame: 21 days (average) ]

How many days did the mechanical ventilation continue


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • PICU stay [ Time Frame: 28 days (average) ]
    How many days did the child spend on PICU
  • Ability to walk [ Time Frame: 4 weeks from PICU discharge ]
    Ability of the child to walk unaided at 4 weeks from PICU admission


Original Secondary Outcome: Same as current

Information By: Mansoura University Children Hospital

Dates:
Date Received: March 1, 2011
Date Started: January 2007
Date Completion:
Last Updated: March 1, 2011
Last Verified: February 2011