Clinical Trial: Study of the Relationship Between Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease: A New Comorbidity or Secondary Consequence

Brief Summary: The purpose of this research study is to understand the relationship between inflammatory bowel disease (IBD) and Glycogen storage disease (GSD)type Ia. GSD type Ib has been established to have an association with IBD with clinical and histologic features that mirror those of Crohn disease. Development of the disease seems to be related to the defect of neutrophil function in individuals with GSD type Ib and subsequent colonic inflammation. In the last decade, it has become a standard for patients with GSD type Ib and gastrointestinal symptoms to be evaluated for IBD. Patients with GSD type Ia were not recognized to have similar gastrointestinal symptoms until recently. The prevalence of IBD is greater in patients with GSD type Ia versus the general population.

Detailed Summary:

The purpose of this research study is to understand the relationship between IBD and GSD type Ia. The Investigators will be attempting to develop a blood test which will be aimed at the participants diagnosis of IBD.

As a participant in this research study, a blood sample will be collected during your admission to the University of Florida. This will not affect the length of stay of your scheduled visit. There will be no scheduled clinic follow-up.


Sponsor: University of Florida

Current Primary Outcome: Serologic, Genetic and Inflammatory Markers Consistent With Inflammatory Bowel Disease [ Time Frame: 2 weeks ]

Participants who tested positive for Crohn disease, ulcerative colitis, or unspecified inflammatory bowel disease (IBD) on a panel for IBD are reported in the Outcome Measure Data Table.


Original Primary Outcome: Serologic, Genetic and Inflammatory Markers Consistent With Inflammatory Bowel Disease [ Time Frame: 2 weeks ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Florida

Dates:
Date Received: May 10, 2013
Date Started: November 2013
Date Completion:
Last Updated: December 22, 2014
Last Verified: December 2014