Clinical Trial: Effects of N-acetyl Cystein (NAC) Supplementation in G6PD Deficient Individuals After Acute Exercise

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effects of N-acetyl Cystein (NAC) Supplementation in G6PD Deficient Individuals After Acute Exercise

Brief Summary: The purpose of this study is to investigate the effects of N-acetyl Cystein (NAC) supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.

Detailed Summary:

In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of both sexes will be supplemented with either 10 mg/kg of NAC (experimental condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before intervention, all participants will be informed about the study protocol, fill a medical history questionnaire and sign an informed consent form. Moreover, measurements of anthropometric characteristics and physiological parameters, as well as a VO2max test will be performed.

Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.


Sponsor: University of Thessaly

Current Primary Outcome: Change in redox status after exercise [ Time Frame: Before, immediately after and 1 hour after each trial of exercise ]

Indices of blood redox status


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Body composition [ Time Frame: Before and after 4 weeks of NAC supplementation, before and after 4 weeks of placebo ]
    Body fat percentage
  • Blood pressure [ Time Frame: Before and after 4 weeks of NAC supplementation, before and after 4 weeks of placebo ]
    Blood pressure at rest


Original Secondary Outcome: Same as current

Information By: University of Thessaly

Dates:
Date Received: October 12, 2016
Date Started: November 2016
Date Completion: March 2017
Last Updated: October 14, 2016
Last Verified: October 2016