Clinical Trial: Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

Study Status: Terminated
Recruit Status: Unknown status
Study Type: Interventional

Official Title: The Effect of Resveratrol in Older Adults With Impaired Glucose Tolerance: a Double-Blind Crossover Study

Brief Summary: Resveratrol is a substance found in many plants, including grapes and red wine, which is widely used as a nutritional supplement. Studies in cells and lower animals show that resveratrol has many potential benefits, including prolonging lifespan, preventing cancer and heart disease and normalization of glucose metabolism. Although use of this agent shows great promise in the treatment and/or prevention of diabetes, there have been no studies reported to date in humans. As an initial step, this proposal is for a 6 week pilot study of resveratrol treatment in older adults with impaired glucose tolerance (IGT) in order to explore its effects on post-meal blood glucose metabolism. Preliminary studies will also be conducted to explore how resveratrol works by studying cellular function (in muscle samples obtained from study participants) and by testing resveratrol's effect on blood vessel function.

Detailed Summary:
Sponsor: Albert Einstein College of Medicine, Inc.

Current Primary Outcome: post meal glucose area under the curve [ Time Frame: end of each of two 6 week treatment periods ]

Original Primary Outcome: Same as current

Current Secondary Outcome: insulin sensitivity [ Time Frame: end of each of two 6 week treatment periods ]

Original Secondary Outcome: Same as current

Information By: Albert Einstein College of Medicine, Inc.

Dates:
Date Received: May 12, 2011
Date Started: April 2011
Date Completion: April 2014
Last Updated: June 16, 2011
Last Verified: June 2011