Clinical Trial: Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Role of CD4+CD25+FoxP3+ Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Brief Summary: Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Current Primary Outcome: proportion averages of cells CD4+CD25+CD127 low T in peripheral blood [ Time Frame: inclusion ]

Original Primary Outcome: proportion of CD4+CD25+CD127 low T cells in peripheral blood [ Time Frame: inclusion ]

Current Secondary Outcome: average relative expression of genes FoxP3, CTLA4, GITR, IL10, TGF-B, OX40, TIM-1, and TIM-3 [ Time Frame: inclusion ]

Original Secondary Outcome: gene expression of FoxP3, CTLA4, GITR, IL10, TGF-B, OX40, TIM-1 et TIM-3 [ Time Frame: inclusion ]

Information By: Centre Hospitalier Universitaire de Saint Etienne

Dates:
Date Received: August 27, 2007
Date Started: April 2008
Date Completion:
Last Updated: September 28, 2010
Last Verified: September 2010