Clinical Trial: Effects of Systemic NO-Inhibition on Renal Hemodynamics in Patiens With Polycystic Kidney Disease and Chronic Glomerulonephritis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Phase 1 Study of Systemic Effects of Ng-Monomethyl-L-Arginine on Renal Hemodynamics in Patients With Polycystic Kidney Disease and Chronic Glomerulonephritis
Brief Summary: The study tests the hypothesis that systemic and renal nitric oxide availability is changed in polycystic kidney disease and chronic glomerulonephritis.
Detailed Summary:
In a randomized, placebo controlled design, the effects of systemic treatment with monomethyl-L-arginine are studied on:
- renal hemodynamics
- renal sodium excretion and lithium clearance
- blood pressure and heart rate
- plasma levels of vasoactive hormones
in patients with adult polycystic kidney disease and chronic glomerulonephrits. The results are compared with a group of healthy control subjects
Sponsor: Regional Hospital Holstebro
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Regional Hospital Holstebro
Dates:
Date Received: June 24, 2006
Date Started:
Date Completion:
Last Updated: June 24, 2006
Last Verified: June 2006
