Clinical Trial: Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title:
Brief Summary:
OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N).
II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.
Detailed Summary:
PROTOCOL OUTLINE:
Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.
Sponsor: National Center for Research Resources (NCRR)
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: National Center for Research Resources (NCRR)
Dates:
Date Received: October 18, 1999
Date Started: January 1998
Date Completion:
Last Updated: June 23, 2005
Last Verified: April 2002