Clinical Trial: Recurrent Glomerulonephritis After Renal Transplantation

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Recurrent Primary Glomerulonephritis After Renal Transplantation: Effects on Renal Allografts and Transplant Recipients

Brief Summary: Glomerulonephritis (GN) is the leading cause of end-stage renal disease in 30% to 50% of patients who receive a renal transplant. The exact prevalence of either recurrent or de novo GN is unknown since a considerable number of patients never undergo allograft biopsy, leaving GN underdiagnosed. The aim of this study is to evaluate the effects of recurrent GN on the prevalence, risk factors, clinicopathological features, and outcome of renal transplant recipients.

Detailed Summary: Glomerulonephritis is the leading cause of end-stage renal disease in 30% to 50% of patients who receive a renal transplant. Even though recurrent or de novo posttransplant primary GN is the third most frequent cause of renal allograft loss after renal transplantation, different recurrence rates have been reported in different patient series worldwide. With the implementation of diverse and improved immunosuppressive treatment regimens and prolongation of graft survival, renal allograft loss caused by recurrent or de novo GN will be more important than ever. Data obtained from comparing patients who have recurrent primary GN against patients with non-recurrent GN and renal transplant recipients with non-GN etiology shall bring new approaches to the daily practice of managing patients with GN and renal failure, assessing them as transplant candidates and applying new therapies.
Sponsor: Istanbul University

Current Primary Outcome: Allograft survival [ Time Frame: 1 - 5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Allograft rejection [ Time Frame: 1 - 5 years ]

Original Secondary Outcome: Same as current

Information By: Istanbul University

Dates:
Date Received: February 25, 2016
Date Started: March 2015
Date Completion:
Last Updated: April 3, 2016
Last Verified: April 2016