Clinical Trial: Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Evaluation of Clinical Efficacy of Pentoxifylline on Patients With Glomerulonephritis
Brief Summary: we hypothesize that PTX might be effective in lowering proteinuria by modulating renal MCP-1 production in human glomerulonephritis.
Detailed Summary: Pentoxifylline (PTX) is a phosphodiesterase inhibitor that is widely used for the treatment of peripheral vascular occlusive disorders. In addition, PTX has shown its ability to attenuate nephrotic syndrome secondary to membranous glomerulonephritis and lupus nephritis, and to reduce subnephrotic proteinuria due to early and advanced diabetic nephropathy. However, data with respect to its effect on non-nephrotic primary glomerular diseases are lacking. Moreover, while the anti-proteinuric effect of PTX has been largely attributed to down-regulation of TNF-a, it remains unknown whether other mediators, especially MCP-1, are also affected by PTX. Because our previous works have shown that PTX attenuates proteinuria and suppresses renal MCP-1 mRNA expression in experimental glomerulonephritis in rats, we hypothesize that PTX might be effective in lowering proteinuria by modulating renal MCP-1 production in human glomerulonephritis. This study was thereby conducted to investigate the potential anti-proteinuric and anti-MCP-1 effects of PTX in subnephrotic patients with primary glomerular diseases.
Sponsor: National Taiwan University Hospital
Current Primary Outcome: proteinuria
Original Primary Outcome: Same as current
Current Secondary Outcome: inflammatory mediators
Original Secondary Outcome: Same as current
Information By: National Taiwan University Hospital
Dates:
Date Received: September 8, 2005
Date Started: January 2000
Date Completion: June 2001
Last Updated: September 8, 2005
Last Verified: June 2001