Clinical Trial: Titanium Prepared Platelet Rich Fibrin for Multiple Gingival Recessions

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effectiveness and Predictability of Titanium-Prepared Platelet-Rich Fibrin for the Management of Multiple Gingival Recessions

Brief Summary:

Objective: Titanium-prepared platelet-rich fibrin (T-PRF) is activated with titanium, which results in a more mature and aggregated form than PRF. In our previous studies, we established that the fibrin carpet formed with titanium had a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed with glass. The purpose of this randomized controlled clinical trial is to compare the effects of autogenous T-PRF and CTG.

Materials and methods: A total 114 Miller Class I/II gingival recessions with abrasion defects will be treated either T-PRF (63 teeth) or CTG (51 teeth) using a modified tunnel technique. Clinical periodontal indexes, keratinized tissue (KTW), gingival thickness (GT) and recession depth (RD) will be recorded before surgery and at 6 and 12-month follow-up examinations. The Visual Analog Scale and healing index scores will be assessed.


Detailed Summary:

A total of 34 patients will be informed in detail about the risks and benefits of each step of the study, and their signed consents will be obtained.

These clinical assessments will be done:

  1. Plaque Index and Gingival Index In case of multiple gingival recessions, plaque index and gingival index will be obtained from the three dental points as mesial, distal and vestibule midpoints; plaque index will be calculated according to Sillnes&Löe criteria, whereas gingival index will be calculated according to Löe&Silness criteria.
  2. Periodontal Pocket Depth In case of multiple gingival recessions, the distance between the pocket base and free gingival margin will be measured separately for each tooth with the assistance of periodontal Williams probe through the midpoint of vestibule.
  3. Recession Width Periodontal probe will be horizontally placed on the enamel-cement border and the measurement will be recorded.
  4. Recession Depth The defect distance will be measured vertically from the enamel-cement conjunction of the tooth to the very apical aspect of the gingival margin using periodontal probe and recorded in millimeters.
  5. Clinical Attachment Level The clinical attachment level (CAL) will be measured by periodontal probe through the midpoint of vestibule as the distance between gingiva base and enamel-cement border and recorded in millimeters.
  6. Keratinized Tissue Width The distance between gingival margin and alveolar mucosa will be measured in millimeters. A solution consisted of 10% potassium iodide and 5% iodine will be applied onto the gingiva and alveolar mucosa with a cotton pellet. This solution stains the gly
    Sponsor: Karadeniz Technical University

    Current Primary Outcome: Root Coverage Percentage at 12 months [ Time Frame: Change from baseline Root Coverage Percentage at 12 months ]

    Preoperative recession depth - Postoperative recession depth X 100 % Preoperative recession depth


    Original Primary Outcome: Same as current

    Current Secondary Outcome: Keratinized Tissue Width at 12 months [ Time Frame: Change from baseline Keratinized Tissue Width at 12 months ]

    The distance between gingival margin to mucogingival junction


    Original Secondary Outcome: Same as current

    Information By: Karadeniz Technical University

    Dates:
    Date Received: April 5, 2017
    Date Started: May 21, 2014
    Date Completion:
    Last Updated: April 21, 2017
    Last Verified: April 2017