Clinical Trial: Platelet Rich Fibrin in the Treatment of Multiple Gingival Recessions

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of Platelet Rich Fibrin and Connective Tissue Graft in Treatment of Multiple Gingival Recessions

Brief Summary: The aim of this randomized controlled clinical study is to evaluate and compare the effectiveness of platelet rich fibrin (PRF) and connective tissue grafts in the treatment of multiple gingival recessions.

Detailed Summary:

The aim of this randomized controlled clinical study is to evaluate and compare the effectiveness of platelet rich fibrin (PRF) and connective tissue grafts in the treatment of multiple gingival recessions.

Primary outcome variables were percentage of complete root coverage and mean root coverage percentages at 6 months follow up. The secondary outcome variables include keratinized tissue and gingival thickness gain.

Sample size has been estimated as 13 in each treatment arm. All recessions are treated with modified coronally advanced flap. On test sites PRF membrane and on control sites connective tissue grafts will be placed under modified coronally advanced flaps. Random allocation of the treatment sites to test and control groups were performed using a computer software designed for randomization.

Clinical parameters such as gingival index, plaque index, keratinized tissue width, gingival recession depth and width were measured at 1, 3 and 6 months. Probing pocket depth, clinical attachment level, gingival thickness and gingival recession area were measure at baseline and 6 months. All gingival recession-related parameters such as recession height, recession width and recession area and keratinized tissue width along with mean root coverage and complete root coverage were assessed on standardized clinical photographs using an image analysis software.

Clinical photographs were obtained at baseline and 1, 3 and 6 months after surgical intervention. 4 mm length wire was placed on gingiva to check reproducibility and to obtain standardized pictures.

Gingival tissue thickness were measured with an #15 endodontic reamer attached to rubber stopper inserted perpendicularly into t
Sponsor: Ege University

Current Primary Outcome:

• Mean root coverage percentage [ Time Frame: 6 months ]
  mean area of root coverage achieved by surgical root coverage therapy.
• complete root coverage percentage [ Time Frame: 6 months ]
  percentage of gingival recession defects completely covered by flaps after 6 months

Original Primary Outcome: Same as current

Current Secondary Outcome:

• keratinized tissue width [ Time Frame: 6 months ]
  changes in keratinized tissue width at 6 months
• gingival tissue thickness [ Time Frame: 6 months ]
  changes from baseline in gingival tissue thickness at 6 months

Original Secondary Outcome: Same as current

Information By: Ege University

Dates:
Date Received: December 17, 2013
Date Started: May 2012
Date Completion:
Last Updated: December 20, 2013
Last Verified: December 2013