Clinical Trial: Concentrated Growth Factor in the Treatment of Gingival Recessions

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Concentrated Growth Factor Membrane in the Treatment of Adjacent Multiple Gingival Recessions: A Split Mouth Randomized Clinical Study

Brief Summary: This study hypothesized that Concentrated Growth Factors'(CGF) placement together with Coronally Advanced Flap (CAF) may enhance the healing of soft tissues. Therefore, the aim of this study was to determine the clinical effect of CGF combination with CAF compared to CAF alone in the treatment of adjacent multiple gingival recessions.

Detailed Summary:

The gingival recessions have been successfully treated by several periodontal plastic surgery procedures. Among the different types of procedures used, Coronally Advanced Flap (CAF) was the most frequent approach, and when combined with a connective tissue graft is accepted as a gold standard therapy. Recently, investigators reported the use of CGF in the reconstruction of bone defects. They concluded that bone formation had significantly increased by using CGF It has been used to accelerate new bone formation associated with guided bone regeneration in sinus augmentation.They stated that CGF may have a better regenerative capacity and high versatility. Therefore, this study hypothesized that CGFs' placement together with CAF may enhance the healing of soft tissues. Therefore, the aim of this study was to determine the clinical effect of CGF combination with CAF compared to CAF alone in the treatment of adjacent multiple gingival recessions.

The patients of this randomized, split mouth and controlled clinical trial study protocol were selected from individuals referred to the Department of Periodontology, at Faculty of Dentistry, Bülent Ecevit University, for either dentin hypersensitivity or aesthetic complaints between April 2013 and April 2014.

All the subjects received oral hygiene instructions and full-mouth scaling were performed 1 month before surgery. They were instructed to perform a non-traumatic brushing technique (Roll) using an ultra soft toothbrush. In twenty subjects (mean age 37.10 ±1.03, 20-45years, 13 females, 7 males), one side of the jaw received CAF (control sites)( 59 defects), the opposite site received CAF+CGF (test sites) (60 defects).

Full-mouth Plaque index and Gingival index were evaluated before surgery. Custom acrylic guides were fabr
Sponsor: Bulent Ecevit University

Current Primary Outcome: Complete root coverage [ Time Frame: 6 months ]

Change from baseline in percentage of complete root coverage at 6th months.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Percentage root coverage [ Time Frame: 6 months ]
    Change from baseline in percentage of root coverage at at 6th months.
  • Keratinized gingiva width [ Time Frame: 6 months ]
    The distance is from the mucogingival junction (MGJ) to the gingival margin
  • Recession depth [ Time Frame: 6 th months ]
    The distance is from the cemento-enamel junction to the gingival margin
  • Gingival Thickness [ Time Frame: 6 months ]
  • Probing depth [ Time Frame: 6 months ]
    The distance is from the gingival margin to the bottom of the sulcus
  • Clinical attachment loss [ Time Frame: 6 months ]
    The distance is from the cemento-enamel junction to the bottom of the sulcus.


Original Secondary Outcome: Same as current

Information By: Bulent Ecevit University

Dates:
Date Received: March 2, 2015
Date Started: April 2013
Date Completion:
Last Updated: March 5, 2015
Last Verified: March 2015