Clinical Trial: Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Platelet Rich Fibrin Against Connective Tissue Graft in Treatment of Gingival Recessions

Brief Summary: The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin membrane used in combination with a coronally advanced flap and to compare it with the use of a subepitelial connective tissue graft in combination with a coronally advanced flap in Miller class I-II bilateral gingival recession treatment

Detailed Summary:

Purpose

The main objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin (PRF) in combination with modified coronally advanced flap (MCAF) in the treatment of multiple gingival recessions. Furthermore the second aim of the present study was to compare plastic periodontal surgical procedure, with PRF membrane and connective tissue graft, by a randomized splitmouth controlled study.

Clinical effectiveness of platelet-rich fibrin (PRF) in combination with modified coronally advanced flap (MCAF) as measured by Clinical measurements.

Material and Methods

Twenty patients with multiple gingival recession defects (Miller I, II) participated in this split-mouth trial. Sixty defects received either MCAF+PRF (test) or MCAF with subepithelial connective tissue graft (SCTG) (control). Gingival recession depth (RD), gingival recession width (RW), keratinized tissue width (KTW), recession area (RA), probing depth (PD), clinical attachment level (CAL) and gingival thickness (GT) were evaluated at baseline and 6 months. Additionally post-surgery patient satisfaction and pain status were measured by comparing visual analogue scale (VAS) scores.

Clinical measurements were taken at starting point and 6 months postoperatively. The measurements comprised an assessment of probing depth (PD),clinical attachment level (CAL) and gingival recession parameters including recession depth (RD), recession width (RW), keratinized tissue width (KTW) and gingival thickness (GT) were assessed by a calibrated examiner (E. Ö.). PD, CAL, RD, RW and KTW values were recorded by a Williams probe graduated in 1-mm increments and rounded up to the nearest millimeter (Hu Friedy, C
Sponsor: Necmettin Erbakan University

Current Primary Outcome:

• Complete root coverage [ Time Frame: 6 months ]
  Change from baseline in gingival recession will be assessed at 1, 3 and 6 months.
• Gingival recession depth [ Time Frame: 6 months ]
  Change from baseline in gingival recession will be assessed at 6 months

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Keratinized tissue width [ Time Frame: 6 months ]
  Change from baseline in keratinized tissue at 6 months.
• Pain scores [ Time Frame: first week after operations ]
  Pain level evaluated on visual analog scale

Original Secondary Outcome: Same as current

Information By: Necmettin Erbakan University

Dates:
Date Received: December 13, 2014
Date Started: January 2014
Date Completion:
Last Updated: January 7, 2015
Last Verified: January 2015