Clinical Trial: Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effects of Anti-Giardia and Antihelmintic Treatment on Infant Nutritional and Biochemical Status and Intestinal Permeability in Rural Bangladesh

Brief Summary: This longitudinal study aimed to assess whether regular anti-Giardia and antihelmintic treatment improved growth and small intestinal mucosal function of rural Bangladeshi infants.

Detailed Summary: A randomised double-blind controlled intervention of 36 weeks duration was conducted in a rural community located 40kms north-west of Dhaka, the capital of Bangladesh. Infants aged between 3 and 11 months were randomly assigned to either receiving anti-Giardia and antihelmintic treatment, or anti-Giardia treatment only, or a control group receiving placebos. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal permeability (L/M ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, immunoglobulin G and Giardia intestinalis specific IgM titre (GSIgM) and eggs of the three common geohelminths and Giardia intestinalis cysts were determined.
Sponsor: University of Cambridge

Current Primary Outcome: nutritional status [ Time Frame: 9 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: intestinal permeability [ Time Frame: 9 months ]

Original Secondary Outcome: Same as current

Information By: University of Cambridge

Dates:
Date Received: January 22, 2008
Date Started: June 2003
Date Completion:
Last Updated: February 4, 2008
Last Verified: January 2008