Clinical Trial: Cytokines and Chemokines in Erythema Migrans

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans

Brief Summary: The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis and to define new immune modulators that could serve as biomarkers of disease activity.

Detailed Summary:
Sponsor: University Medical Centre Ljubljana

Current Primary Outcome: inflammatory proteins in erythema migrans patients [ Time Frame: up to 12 months follow-up ]

The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses in serum and if available, skin, of patients during active infection and after treatment.


Original Primary Outcome: Same as current

Current Secondary Outcome: gene polymorphisms in erythema migrans patients [ Time Frame: at enrollment ]

The expression of disease-relevant genomic variants will be assessed using ImmunoChip.


Original Secondary Outcome: Same as current

Information By: University Medical Centre Ljubljana

Dates:
Date Received: June 24, 2013
Date Started: July 2013
Date Completion:
Last Updated: May 4, 2017
Last Verified: May 2017