Clinical Trial: Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Genetic Risk Factors for Gastrointestinal Stromal Tumors (GIST)

Brief Summary:

RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.

PURPOSE: This research study is looking at tumor samples in patients undergoing treatment for gastrointestinal stromal tumors on clinical trial ACOSOG-Z9001.


Detailed Summary:

OBJECTIVES:

Primary

  • To examine polymorphisms in selected genes involved in the detoxifying/metabolizing and DNA repair pathways in relation to specific mutations and types of mutation in the c-kit gene in tumor tissue from patients with gastrointestinal tumors (GIST) undergoing treatment on clinical trial ACOSOG-Z9001.

Secondary

  • To examine approximately 758 polymorphisms among candidate genes involved in detoxification/metabolism, cell cycle control, and DNA damage/repair in relation to specific mutations and types of mutation in the c-kit gene in tumor tissue from GIST patients for hypothesis generation. (exploratory)
  • To conduct an exploratory analysis of the polymorphism distribution in these patients. (exploratory)
  • To examine the association between the above polymorphisms and major toxicity (Grade 3/4) of adjuvant imatinib mesylate. (exploratory)

OUTLINE: Tumor samples are used for polymorphism and mutation analysis.


Sponsor: Alliance for Clinical Trials in Oncology

Current Primary Outcome: response [ Time Frame: Up to 5 years ]

Original Primary Outcome: Polymorphisms in selected genes in relation to specific mutations and types of mutation in the c-kit gene

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Alliance for Clinical Trials in Oncology

Dates:
Date Received: August 6, 2009
Date Started: December 2008
Date Completion:
Last Updated: June 24, 2016
Last Verified: June 2016