Clinical Trial: Capsule Endoscopy or Mesenteric Angiogram in Patients With Overt Gastrointestinal Bleeding (GIB) of Obscure Origin

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Capsule Endoscopy or Mesenteric Angiogram in Patients With Overt Gastrointestinal Bleeding of Obscure Origin: A Randomized Study

Brief Summary: To compare the diagnostic yield of mesenteric angiogram with CE in patients with active obscure GIB.

Detailed Summary: Gastrointestinal bleeding (GIB) of obscure origin is a common conditions resulting in recurrent hospitalization and extensive investigations. Mesenteric angiogram is one of the standard radiological investigations for GIB of obscure origin, and its diagnostic yield ranged from 40-80%. Capsule endoscopy (CE) is a newly available investigation for small bowel examination, especially in bleeding of obscure origin. The diagnostic yield is particularly high in patients with ongoing bleeding. This is a prospective randomized study to compare the diagnostic yield of mesenteric angiogram with CE in patients with overt GIB of obscure origin. The results will help to define the optimal management strategy for this group of patients.
Sponsor: Chinese University of Hong Kong

Current Primary Outcome: Diagnostic yield of CE and mesenteric angiogram as the primary investigation after negative EGD and colonoscopy. [ Time Frame: 12 months ]

Original Primary Outcome: Diagnostic yield of CE and mesenteric angiogram as the primary investigation after negative EGD and colonoscopy.

Current Secondary Outcome: Percentage of patients with definitive diagnoses achieved;Length of stay (days) ;Transfusion requirements;No. of additional investigations (endoscopies, radiological investigation, CE etc);No. of patients requiring surgery ;12-month rebleeding rate [ Time Frame: 12 months ]

Original Secondary Outcome:

Information By: Chinese University of Hong Kong

Dates:
Date Received: September 8, 2005
Date Started: June 2005
Date Completion:
Last Updated: May 9, 2008
Last Verified: May 2008