Clinical Trial: Predictive Role of Red Cell Distribution Width in Upper GI Bleeding Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Efficacy of Red Cell Distribution Width as a Predictor of High Risk and Early Mortality in Upper Gastro-intestinal Bleeding

Brief Summary: Acute upper-gastrointestinal bleeding (UGIB) is a commonly encountered cause of admission in emergency department (ED). Early risk stratification allows appropriate therapy that may be helpful to advance the patient's morbidity and mortality. We hypothesized that early RDW levels may have an independent, linear relationship with recurrent or massive bleeding in UGIB patients.

Detailed Summary:

This is a retrospective clinical study including the UGI patients in ED. All data will be collected through the electrical medical records. The major endpoints are the high risk patients and 30-days mortality which defined cases of including any of one among the death, re-bleeding, and received the intervention (such as blood transfusion, endoscopic therapy and operation).

We assessed the relationship between initial RDW level and high risk patients and 30-days mortality. In addition, we compare the dicrimination power for predicting outcomes between the UGIB scoring system and RDW level.

Univariate and multivariate logistic regression testing and a Cox hazard regression model were used to determine the factors associated with outcome variables. In addition, we constructed receiver operating characteristic curves, and the areas under the curves and confidence intervals were calculated to compare the discriminatory power for outcomes.


Sponsor: Konkuk University Medical Center

Current Primary Outcome: High risk [ Time Frame: 30 days ]

Case of the death or re-bleeding, or blood transfusion or endoscopic therapy or operation.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Konkuk University Medical Center

Dates:
Date Received: April 14, 2017
Date Started: January 1, 2011
Date Completion:
Last Updated: April 18, 2017
Last Verified: April 2017