Clinical Trial: Long-term Follow-up Prognosis of Atrophic Gastritis After 3 Years

Study Status: Completed
Recruit Status: Completed
Study Type: Observational [Patient Registry]

Official Title: Significance of Helicobacter Pylori Infection and Pepsinogen Levels on the Prognosis of Atrophic Gastritis - Observational Study

Brief Summary: Serum pepsinogen (PG) levels are considered reliable markers for progression of atrophic gastritis with a stepwise reduction in the serum PG I level or PG I/II ratio. A combination of serum PG levels and Helicobacter pylori serology are used as a biomarker strategy for detection of individuals at increased risk of gastric neoplasm based on Correa's hypothesis. The investigators aimed to uncover whether this combination method could predict the risk of gastric neoplasms and the progression of chronic atrophic gastritis after 3 years. All the participants will be followed for an expected average of 3 years.

Detailed Summary: According to the Correa's hypothesis, the combination method using serum pepsinogen levels and serum Helicobacter pylori antibody would predict the risk and cell type of gastric neoplasm. However, in endemic regions of H. pylori infection such as in East Asian countries (Korea, Japan, and China), most of the aged population are have current or had past H. pylori infection. Therefore, in this study, we are going to uncover whether the risk of gastric neoplasm is significantly higher in the atrophy(+)/H. pylori(-) group followed by atrophy(+)/H. pylori(+), atrophy(-)/H. pylori(+), and atrophy(-)/H. pylori(-) groups. In addition, we are going to investigate whether those slow-growing gastric neoplasms such as differentiated gastric cancers with Lauren's intestinal type and gastric adenoma are more commonly developed in atrophy group following the Correa's hypothesis, whereas rapid-growing gastric neoplasms such as poorly-cohesive carcinoma or undifferentiated gastric cancers with Lauren's diffuse type are more commonly developed in the subjects without atrophy. Taken as a whole, our study result will provide an evidence whether this biomarker strategy are useful for the detection of individuals at increased risk of gastric neoplasm.
Sponsor: Konkuk University Medical Center

Current Primary Outcome: Newly developed gastric neoplasm [ Time Frame: December 31, 2013 ]

Newly developed gastric neoplasm


Original Primary Outcome: Same as current

Current Secondary Outcome: Degree of gastric atrophy [ Time Frame: December 31, 2013 ]

Degree of gastric atrophy measured by serum pepsinogen I and II levels


Original Secondary Outcome: Same as current

Information By: Konkuk University Medical Center

Dates:
Date Received: March 28, 2013
Date Started: January 2010
Date Completion:
Last Updated: August 15, 2013
Last Verified: August 2013