Clinical Trial: Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Assessing Changes in Social Cognition and Personality in Patients With Frontotemporal Lobar Degeneration, Alzheimer's Disease and Parkinson's Disease and Their Effect on t

Brief Summary: The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.

Detailed Summary: The purpose of this study is to understand social cognition changes in patients with Alzheimer's disease (AD), Parkinson's disease (PD), and Frontotemporal Lobar Degeneration (FTLD), which includes Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS) and Frontotemporal Dementia (FTD - behavioural variant frontotemporal dementia, progressive non-fluent aphasia and semantic dementia), and the effect of these changes on the patients' relationship with their caregivers. In addition, the study aims to provide a greater clarity in the neuroanatomical correlates of social cognition in patients with FTLD, PD and AD.
Sponsor: University Health Network, Toronto

Current Primary Outcome:

  • Personality via the Interpersonal Adjectives Scales and differences between AD, PD, and FTLD [ Time Frame: one time visit, through study completion of 3 years ]
    Assesses interpersonal aspects of personality
  • Personality via the Behaviour Inhibition/Approach Scale (BIS/BAS) and differences between AD, PD, and FTLD [ Time Frame: one time visit, through study completion of 3 years ]
    Assesses the behavioural approach system that regulates appetitive motives, in which the goal is to move toward something desired, and the behavioural avoidance (or inhibition) system that regulates aversive motives, in which the goal is to move away from something unpleasant
  • Personality via the Big Five Inventory (BFI) and differences between AD, PD, and FTLD [ Time Frame: one time visit, through study completion of 3 years ]
    Assesses the patient's Big Five dimensions (openness, conscientiousness, extraversion, agreeableness, and neuroticism) with respect to past and current behavior
  • Social cognition via Social Norms Questionnaire and differences between AD, PD, and FTLD [ Time Frame: one time visit, through study completion of 3 years ]
    Assesses the patient's understanding of culturally relevant social norms
  • Social cognition via Interpersonal Reactivity Index (IRI) and differences between AD, PD, and FTLD [ Time Frame: one time visit, through study completion of 3 years ]
    Assesses the patient's empathy or ability to share in anothe

    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    Original Secondary Outcome:

    Information By: University Health Network, Toronto

    Dates:
    Date Received: September 23, 2016
    Date Started: January 2013
    Date Completion: August 2017
    Last Updated: November 10, 2016
    Last Verified: November 2016