Clinical Trial: Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
Study Status: Terminated
Recruit Status: Unknown status
Study Type: Observational
Official Title: Use of Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
Brief Summary:
The purpose of this study is to
- Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference.
- Evaluate parameters related to the BME of the collapsed vertebral body on DE CT virtual noncalcium images, such as the morphologic signs, visual qualitative detection, and quantitative values.
Detailed Summary:
Patients with multiple compression fractures and in those with chronic fracture, determining which vertebra to treat is frequently difficult. In such patients, the treatment location is commonly determined from findings at imaging, which includes magnetic resonance (MR) imaging, bone scintigraphy, and computed tomography (CT).
The bone marrow edema (BME) in acute/subacute VCFs is useful in determining the vertebra that is to be treated.
MR imaging provides information on anatomic vertebral collapse and the loss of normal T1 high signal intensity from the marrow space of vertebrae with acute fractures. Loss of normal T1 high signal intensity indicates the presence of BME, which is the important sign for the PVP treatment of VCFs.
Dual-energy (DE) CT has been used to create a virtual unenhanced scan by subtracting iodine from contrast agent-enhanced CT examinations.We expect that the same technique can be used to calculate a virtual noncalcium image from an unenhanced image, which makes bone marrow accessible for CT diagnosis.
Sponsor: National Cheng-Kung University Hospital
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: National Cheng-Kung University Hospital
Dates:
Date Received: January 20, 2011
Date Started: January 2011
Date Completion: December 2011
Last Updated: February 9, 2011
Last Verified: January 2011
